In Cardiology

Being overweight or obese creates damaging changes to the structure of the heart, according to new research recently published in the journal, PLoS ONE.

The new research uses UK Biobank data to reveal – for the first time – the direct damage that carrying extra weight has on the heart’s weight and size, and implicates a range of other modifiable risk factors, including high blood pressure.

Researchers at Queen Mary University of London (QMUL) and the University of Oxford, and funded by the British Heart Foundation, used cardiac magnetic resonance imaging to carefully study the structure and function of the hearts of 4,561 people from the UK Biobank database.

After adjusting for risk factors that can’t be modified, the team were able to measure the effects of a range of lifestyle risk factors on the four chambers of the heart.

They showed that these risk factors could all have varying effects on the heart, but an overall increased heart weight was linked to overweight and obese individuals.
Previous studies have definitively proven the link between high BMI and heart disease but have predominantly shown how it increases blood pressure, cholesterol and the risk of developing diabetes, which are all independent risk factors for heart disease. This new study was able to see and measure the direct damage that modifiable risk factors have on the structure and function of the heart.

Professor Steffen Petersen, lead author at QMUL, explained, ‘We all know that our lifestyle has a big impact on our heart health – particularly if we’re overweight or obese. But researchers haven’t fully understood how exactly the two things are linked.

‘With this research, we’ve helped to show how an unhealthy lifestyle increases your risk of heart disease. BMI and blood pressure in particular led to heavier and bigger hearts, which increases the risk of heart problems, including heart attacks.’

Meanwhile, Professor Sir Nilesh Samani, Medical Director of the British Heart Foundation, said, ‘This research shows the silent impact of being overweight and having high blood pressure on the structure and function of the heart, which over time may lead to heart disease and heart failure.

‘The important message is that these are things we have the power to change before they result in irreversible heart damage.’

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