Children and young people in the UK with cancers that have come back can now access new personalised treatments quicker than ever before thanks to a national tumour biopsy sequencing platform and clinical trial funded by Cancer Research UK.
The genetic code of tumours are sequenced through the Stratified Medicine Paediatrics programme, and the molecular information is used to match patients to treatments on the ESMART trial, which is testing multiple new targeted drugs, and treatment combinations not previously available for children and young people.
Patients may be placed on ESMART within just a few weeks of having their tumours sequenced, offering children and young people with cancer who have limited treatment options quick access to the targeted drugs most likely to work for them.
The Stratified Medicine Paediatrics programme is being run by The Institute of Cancer Research, London, and the ESMART is a European trial that is currently being rolled out across the UK. It is open at the trial’s lead centre, The Royal Marsden NHS Foundation Trust in London, and the Royal Manchester Children’s Hospital. Further sites are to open in Birmingham, Newcastle and Great Ormond Street Hospital over the next few months
Cancer in children and young people is rare, and when it does occur, more than 80% of those diagnosed survive their cancer for 5 years or more. However, this includes more common and, generally, more curable cancers. For more aggressive cancers such as neuroblastomas, and cases where cancer spreads or comes back after initial treatment, survival can be much lower and treatment options are fewer.
For the last two years in the UK, when a young person’s cancer comes back, their tumour has been routinely sequenced through the Stratified Medicine Paediatrics programme. The findings are discussed by an expert panel of clinicians and scientists who recommend potential treatment options based on the specific gene faults identified in the tumour. But treatments have been very limited, and clinical trials often only test combinations of existing chemotherapy drugs or radiotherapy, or single molecularly targeted drugs.
The new ESMART clinical trial is now open in the UK and has been developed to radically widen the scope of treatments available for children and young people. Currently, the trial has 10 treatment arms (plus 5 more that are waiting regulatory approval) that are testing an array of therapies on their own or in combination, including targeted drugs, immunotherapies, radiotherapy and chemotherapy. And as researchers develop promising new drugs, they are quickly rolled into the study.
Professor Louis Chesler, who leads the Stratified Medicine Paediatrics programme at The Institute of Cancer Research, London, said: “Our Stratified Medicine Paediatrics programme goes beyond the traditional DNA sequencing of tumours, because the platform also gives us valuable information on specific features of the tumour that could be targeted by precision medicines. This was a big step forward, and it’s brilliant to now also have access to the newest treatments that we know could work for our patients.
“Combined with the ESMART trial, the Stratified Medicine Paediatrics programme gives us an outstanding array of treatments and combinations to choose from to give children and young people the best possible treatment options for them. Combined with our ongoing work of improving the diagnosis of young people’s cancer, and understanding more about what is causing treatment resistance and relapse, the future is looking more optimistic for our young patients, which is fantastic news for them and their families.”